Abstract Endosomal nucleic acid sensing by Toll-like receptors (TLRs) is central to antimicrobial immunity and several autoimmune conditions such as systemic lupus erythematosus (SLE).The innate immune adaptor TASL mediates, via the interaction with SLC15A4, the activation of IRF5 downstream of human TLR7, TLR8 and TLR9, but the pathophysiological
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Aim.To study left atrial (LA) deformation in patients with arterial hypertension, aortic stenosis (AS) and left ventricular hypertrophy (LVH) of different severity.Material and methods.LA deformation was studied in 20 healthy subjects and 68 patients.Of them 30 patients had AH and mild LVH, 22-AH 3 Pc. Sectional and manifest LVH, 16patients had AS.